End-to-end custom clinical sequencing solutions

Our dedicated project managers find custom solutions to support you from experimental design through phase III clinical trials.

Solutions for pharmacogenomic and biomarker discovery

Scientists everywhere have access to the latest technologies and expert guidance at the Broad Institute. Our team of clinical sequencing experts will partner with you to design comprehensive, end-to-end custom services using the latest methods to help you meet your clinical research goals.

From experimental planning and sample preparation through phase III clinical trial testing, you can count on our experience to deliver data that drives biomarker discovery and therapeutic development.

Our custom service offerings

  • Custom selection panels
  • WGS-based gene panel interpretation
  • Clinical and pre-clinical experimental planning
  • WGS & WES-based population screening
  • WGS & WES-based PRS analysis
  • PRS validation

Don’t see what you are looking for? We can design a solution for you.

See what our custom project clients are saying

The Broad CRSP is great at scaling. We’ve been able to initiate sequencing projects really rapidly, and they are flexible when it comes to sample sizes.

The Broad CRSP has a cluster of very strong scientists from different backgrounds with the expertise to really produce the best possible quality data.

Biomarker detection case study

Sensitive detection of molecular biomarkers in custom gene panels in support of clinical trials: sequencing under a quality system

  • Validation of 1,000 samples with a hematological custom target panel
  • 98.6% of targets covered at >20x
  • Custom-built LIMS and bioinformatic pipeline

A typical custom clinical panel workflow


scope and custom panel design


assay and measure clinical sensitivity


validation plan and key deliverables


validation, finalize report, implement clinical test


project and write report

Looking for a custom solution for your next project?

Learn how we can help.